Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma
Identifieur interne : 008149 ( Main/Exploration ); précédent : 008148; suivant : 008150Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma
Auteurs : Maurits N. C. De Koning [Pays-Bas] ; Sonke Jan Weissenborn [Allemagne] ; Damiano Abeni [Italie] ; Jan Nico Bouwes Bavinck [Pays-Bas] ; Sylvie Euvrard [France] ; Adele C. Green [Australie] ; Catherine A. Harwood [Royaume-Uni] ; Luigi Naldi [Italie] ; Rachel Neale [Australie] ; Ingo Nindl [Allemagne] ; Charlotte M. Proby [Royaume-Uni] ; Wim G. V. Quint [Pays-Bas] ; Francesca Sampogna [Italie] ; Jan Ter Schegget [Pays-Bas] ; Linda Struijk [Pays-Bas] ; Ulrike Wieland [Allemagne] ; Herbert J. Pfister [Allemagne] ; Mariet C. W. Feltkamp [Pays-Bas]Source :
- Journal of general virology [ 0022-1317 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n=845) and immunosuppressed (n=560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UV-irradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91 % in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98% in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not.
Affiliations:
- Allemagne, Australie, France, Italie, Pays-Bas, Royaume-Uni
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, District de Cologne, District de Karlsruhe, Grand Londres, Hollande-Méridionale, Latium, Rhénanie-du-Nord-Westphalie, Rhône-Alpes
- Cologne, Heidelberg, Leyde, Londres, Lyon, Rome
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De Koning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>DDL Diagnostic Laboratory</s1><s2>Voorburg</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>DDL Diagnostic Laboratory</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jan Weissenborn, Sonke" sort="Jan Weissenborn, Sonke" uniqKey="Jan Weissenborn S" first="Sonke" last="Jan Weissenborn">Sonke Jan Weissenborn</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Cologne</s1><s2>Köln</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Istituto Dermopatico dell'Immacolata IDI-IRCCS</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Dermatology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Dermatology, Hospital Edouard Herriot</s1><s2>Lyon</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C." last="Green">Adele C. Green</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A." last="Harwood">Catherine A. Harwood</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Dermatology and GISED Study Center, Ospedali Riuniti</s1><s2>Bergamo</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Neale, Rachel" sort="Neale, Rachel" uniqKey="Neale R" first="Rachel" last="Neale">Rachel Neale</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>DKFZ - Charité, Viral Skin Carcinogenesis, Division Viral Transformation Mechanisms, German Cancer Research Center (DKFZ)</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M." last="Proby">Charlotte M. Proby</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G. V." last="Quint">Wim G. V. Quint</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>DDL Diagnostic Laboratory</s1><s2>Voorburg</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>DDL Diagnostic Laboratory</wicri:noRegion></affiliation></author><author><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Istituto Dermopatico dell'Immacolata IDI-IRCCS</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ter Schegget, Jan" sort="Ter Schegget, Jan" uniqKey="Ter Schegget J" first="Jan" last="Ter Schegget">Jan Ter Schegget</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>DDL Diagnostic Laboratory</s1><s2>Voorburg</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>DDL Diagnostic Laboratory</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Struijk, Linda" sort="Struijk, Linda" uniqKey="Struijk L" first="Linda" last="Struijk">Linda Struijk</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Cologne</s1><s2>Köln</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Pfister, Herbert J" sort="Pfister, Herbert J" uniqKey="Pfister H" first="Herbert J." last="Pfister">Herbert J. Pfister</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Cologne</s1><s2>Köln</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C. W." last="Feltkamp">Mariet C. W. Feltkamp</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0295139</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0295139 INIST</idno><idno type="RBID">Pascal:09-0295139</idno><idno type="wicri:Area/PascalFrancis/Corpus">002D29</idno><idno type="wicri:Area/PascalFrancis/Curation">003291</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002917</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002917</idno><idno type="wicri:doubleKey">0022-1317:2009:De Koning M:prevalence:and:associated</idno><idno type="wicri:Area/Main/Merge">008886</idno><idno type="wicri:Area/Main/Curation">008149</idno><idno type="wicri:Area/Main/Exploration">008149</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prevalence and associated factors of betapapillomavirus infections in individuals without cutaneous squamous cell carcinoma</title><author><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N. C." last="De Koning">Maurits N. C. De Koning</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>DDL Diagnostic Laboratory</s1><s2>Voorburg</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>DDL Diagnostic Laboratory</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Jan Weissenborn, Sonke" sort="Jan Weissenborn, Sonke" uniqKey="Jan Weissenborn S" first="Sonke" last="Jan Weissenborn">Sonke Jan Weissenborn</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Cologne</s1><s2>Köln</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Istituto Dermopatico dell'Immacolata IDI-IRCCS</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Dermatology, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Dermatology, Hospital Edouard Herriot</s1><s2>Lyon</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C." last="Green">Adele C. Green</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A." last="Harwood">Catherine A. Harwood</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Dermatology and GISED Study Center, Ospedali Riuniti</s1><s2>Bergamo</s2><s3>ITA</s3><sZ>8 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Bergamo</wicri:noRegion></affiliation></author><author><name sortKey="Neale, Rachel" sort="Neale, Rachel" uniqKey="Neale R" first="Rachel" last="Neale">Rachel Neale</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Queensland Institute of Medical Research</s1><s2>Brisbane</s2><s3>AUS</s3><sZ>6 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Queensland Institute of Medical Research</wicri:noRegion></affiliation></author><author><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>DKFZ - Charité, Viral Skin Carcinogenesis, Division Viral Transformation Mechanisms, German Cancer Research Center (DKFZ)</s1><s2>Heidelberg</s2><s3>DEU</s3><sZ>10 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M." last="Proby">Charlotte M. Proby</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University London</s1><s2>London</s2><s3>GBR</s3><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G. V." last="Quint">Wim G. V. Quint</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>DDL Diagnostic Laboratory</s1><s2>Voorburg</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>DDL Diagnostic Laboratory</wicri:noRegion></affiliation></author><author><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Istituto Dermopatico dell'Immacolata IDI-IRCCS</s1><s2>Rome</s2><s3>ITA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Ter Schegget, Jan" sort="Ter Schegget, Jan" uniqKey="Ter Schegget J" first="Jan" last="Ter Schegget">Jan Ter Schegget</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>DDL Diagnostic Laboratory</s1><s2>Voorburg</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>12 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>DDL Diagnostic Laboratory</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Struijk, Linda" sort="Struijk, Linda" uniqKey="Struijk L" first="Linda" last="Struijk">Linda Struijk</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Cologne</s1><s2>Köln</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Pfister, Herbert J" sort="Pfister, Herbert J" uniqKey="Pfister H" first="Herbert J." last="Pfister">Herbert J. Pfister</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Virology, University of Cologne</s1><s2>Köln</s2><s3>DEU</s3><sZ>2 aut.</sZ><sZ>16 aut.</sZ><sZ>17 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Cologne</settlement></placeName></affiliation></author><author><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C. W." last="Feltkamp">Mariet C. W. Feltkamp</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of general virology</title><title level="j" type="abbreviated">J. gen. virol.</title><idno type="ISSN">0022-1317</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betapapillomavirus</term><term>Epidemiology</term><term>Infection</term><term>Microbiology</term><term>Papillomaviridae</term><term>Prevalence</term><term>Skin squamous cell carcinoma</term><term>Virus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus</term><term>Prévalence</term><term>Epidémiologie</term><term>Infection</term><term>Microbiologie</term><term>Carcinome épidermoïde de la peau</term><term>Betapapillomavirus</term><term>Papillomaviridae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Betapapillomavirus (betaPV) infections are often associated with squamous-cell carcinoma (SCC) and the prevalence of betaPV infections in (immunosuppressed) SCC patients is known to be high. The distribution and possible associated factors of betaPV infections in the general population, however, are largely unknown. To address this issue, betaPV infection was studied in 1405 SCC-free immunocompetent (n=845) and immunosuppressed (n=560) individuals from six countries of different latitudes. A standard study protocol was used to obtain information about age, sex, UV-irradiation and skin type, and from all participants eyebrow hairs were collected for detection and genotyping of 25 established betaPV types using the PM-PCR reverse hybridization assay (RHA) method. The frequency of betaPV-positive participants ranged from 84 to 91 % in the immunocompetent population with HPV23 as the most prevalent type, and from 81 to 98% in the immunosuppressed population with HPV23 as the most or the second most prevalent type. The median number of infecting betaPV types ranged from four to six in the immunocompetent and from three to six in the immunosuppressed population. Increasing age in the immunocompetent participants and (duration of) immunosuppression in the immunosuppressed patients were associated with betaPV infection. In both groups, sex, skin phototype, sunburns and sun-exposure were not consistently associated with betaPV infection. This study demonstrates that betaPV infections are also highly prevalent in SCC-free individuals, with similar HPV types prevailing in both immunocompetent and immunosuppressed persons. Age and (duration of) immunosuppression were identified as betaPV infection-associated factors, whereas characteristics related to sun exposure and skin type were not.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Latium</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li></region><settlement><li>Cologne</li><li>Heidelberg</li><li>Leyde</li><li>Londres</li><li>Lyon</li><li>Rome</li></settlement></list><tree><country name="Pays-Bas"><noRegion><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N. C." last="De Koning">Maurits N. C. De Koning</name></noRegion><name sortKey="Bouwes Bavinck, Jan Nico" sort="Bouwes Bavinck, Jan Nico" uniqKey="Bouwes Bavinck J" first="Jan Nico" last="Bouwes Bavinck">Jan Nico Bouwes Bavinck</name><name sortKey="De Koning, Maurits N C" sort="De Koning, Maurits N C" uniqKey="De Koning M" first="Maurits N. C." last="De Koning">Maurits N. C. De Koning</name><name sortKey="Feltkamp, Mariet C W" sort="Feltkamp, Mariet C W" uniqKey="Feltkamp M" first="Mariet C. W." last="Feltkamp">Mariet C. W. Feltkamp</name><name sortKey="Quint, Wim G V" sort="Quint, Wim G V" uniqKey="Quint W" first="Wim G. V." last="Quint">Wim G. V. Quint</name><name sortKey="Struijk, Linda" sort="Struijk, Linda" uniqKey="Struijk L" first="Linda" last="Struijk">Linda Struijk</name><name sortKey="Ter Schegget, Jan" sort="Ter Schegget, Jan" uniqKey="Ter Schegget J" first="Jan" last="Ter Schegget">Jan Ter Schegget</name><name sortKey="Ter Schegget, Jan" sort="Ter Schegget, Jan" uniqKey="Ter Schegget J" first="Jan" last="Ter Schegget">Jan Ter Schegget</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Jan Weissenborn, Sonke" sort="Jan Weissenborn, Sonke" uniqKey="Jan Weissenborn S" first="Sonke" last="Jan Weissenborn">Sonke Jan Weissenborn</name></region><name sortKey="Nindl, Ingo" sort="Nindl, Ingo" uniqKey="Nindl I" first="Ingo" last="Nindl">Ingo Nindl</name><name sortKey="Pfister, Herbert J" sort="Pfister, Herbert J" uniqKey="Pfister H" first="Herbert J." last="Pfister">Herbert J. Pfister</name><name sortKey="Wieland, Ulrike" sort="Wieland, Ulrike" uniqKey="Wieland U" first="Ulrike" last="Wieland">Ulrike Wieland</name></country><country name="Italie"><region name="Latium"><name sortKey="Abeni, Damiano" sort="Abeni, Damiano" uniqKey="Abeni D" first="Damiano" last="Abeni">Damiano Abeni</name></region><name sortKey="Naldi, Luigi" sort="Naldi, Luigi" uniqKey="Naldi L" first="Luigi" last="Naldi">Luigi Naldi</name><name sortKey="Sampogna, Francesca" sort="Sampogna, Francesca" uniqKey="Sampogna F" first="Francesca" last="Sampogna">Francesca Sampogna</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Euvrard, Sylvie" sort="Euvrard, Sylvie" uniqKey="Euvrard S" first="Sylvie" last="Euvrard">Sylvie Euvrard</name></region></country><country name="Australie"><noRegion><name sortKey="Green, Adele C" sort="Green, Adele C" uniqKey="Green A" first="Adele C." last="Green">Adele C. Green</name></noRegion><name sortKey="Neale, Rachel" sort="Neale, Rachel" uniqKey="Neale R" first="Rachel" last="Neale">Rachel Neale</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Harwood, Catherine A" sort="Harwood, Catherine A" uniqKey="Harwood C" first="Catherine A." last="Harwood">Catherine A. Harwood</name></region><name sortKey="Proby, Charlotte M" sort="Proby, Charlotte M" uniqKey="Proby C" first="Charlotte M." last="Proby">Charlotte M. Proby</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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